This comprehensive and up-to-date monograph covers the fundamentals and recent developments in the mathematical modeling of metabolic systems, providing the basis for improved understanding of the behavior and functioning of cells. In particular, it presents state-of-the-art theoretical descriptions of the regulation of enzymatic systems, including coverage of stoichiometric, kinetic, and control and optimality properties. The Regulation of Cellular Systems begins with coverage of enzymatic rate laws and stoichometric analysis. It then presents a detailed account of the interpretation of time hierarchy. A considerable amount of the text is devoted to the next section on metabolic control analysis. The book provides a thorough overview of this topic, from its basic definition to its more detailed and computational aspects. Finally, varius approaches describing optimality properties of enzymatic systems and their interrelations with biological evolution are outlined. Other highlights of this text include metabolic channeling, metabolic oscillations, and modular treatment as well as a multitude of illustrations and an abundant reference list. Providing a theoretical approach to the regulation of cellular processes, this outstanding study will become a valuable additon to the libraries of biochemists, biophysicists, biomathematicians, and physicochemists. It is also an exceptional textbook for faculty and graduate students in departments of cellular and molecular biology, neurobiology, biophysics, and biomedical research departments. (From the back- cover)