Exploration of chronobiological systems is emerging as a growing research field within bioinformatics, focusing on various applications in medicine and agriculture. From a systems biology perspective, the question arises as to whether biological control systems for regulation of oscillatory signals utilize similar mechanisms to their technical counterparts. If so, modelling approaches adopted from building blocks can help to identify general components for frequency control in circadian clocks and can provide insight into mechanisms of clock synchronization to external stimuli like the daily rhythm of sunlight and darkness. Within the Research Initiative in Systems Biology funded by the German Ministry of Education and Research, we develop new methods to cover temporal aspects of ...